Nelfinavir Mesylate
A to Z Drug Facts
Nelfinavir Mesylate |
(nell-FIN-ah-veer) |
Viracept |
Class: Antiviral |
Action Inhibits human immunodeficiency virus (HIV) protease, the enzyme required to form functional proteins in HIV-infected cells.
Indications Treatment of HIV infection. May be given in combination with nucleoside analogues (eg, zidovudine) or as monotherapy.
Contraindications Hypersensitivity to nelfinavir or any component of the product. Concomitant therapy with amiodarone, astemizole, cisapride, ergot-derivatives, quinidine, rifampin and terfenadine. Concurrent therapy with alprazolam, clorazepate, diazepam, estazolam, flurazepam, midazolam, triazolam and zolpidem.
ADULTS & CHILDREN > 13 YR: PO 750 mg tid in combination with nucleoside analogs. CHILDREN 2 to 13 YR: PO 20 to 30 mg/kg/dose tid.
Amiodarone, astemizole, cisapride, quinidine, rifabutin, terfenadine: Nelfinavir may elevate blood levels of these drugs, which may increase the risk of arrhythmias or other potential serious adverse effects. Alprazolam, clorazepate, diazepam, estazolam, flurazepam, midazolam, triazolam, zolpidem: Nelfinavir may increase blood levels of these drugs, which may produce extreme sedation and respiratory depression. Do not coadminister. Rifampin: May decrease plasma concentrations of nelfinavir. Oral contraceptives: Concentrations of ethinyl estradiol, a component of oral contraceptives, may be reduced. Indinavir: Nelfinavir may increase indinavir blood levels. Indinavir, retonavir: May increase nelfinavir plasma concentrations. Carbamazepine, phenobarbital, phenytoin: May decrease nelfinavir plasma concentrations.
Lab Test Interferences None well documented.
CNS: Headache; paresthesia; dizziness; insomnia; somnolence; anxiety; depression; seizures; emotional lability; hyperkinesis. DERM: Rash; pruritus; sweating; urticaria. EENT: Pharyngitis; rhinitis; sinusitus. GI: Anorexia; diarrhea; dyspepsia; flatulence; nausea; vomiting; abdominal pain; pancreatitis; bleeding; mouth ulcerations. GU: Sexual dysfunction; kidney calculus. HEPA: Hepatitis. HEMA: Anemia; leukopenia; thrombocytopenia. META: Increased alkaline phosphotase; liver function tests; creatinine phosphokinase; hyperlipidemia. RESP: Dyspnea. OTHER: Asthenia; fever; myalgia; back pain; malaise; arthralgia; myasthenia; myopathy.
Pregnancy: Category B. Lactation: Undetermined. HIV-infected mothers should not breastfeed their infants. Children: Safety and efficacy not established for children < 2 yr. Hepatic function impairment: Use caution; decreased nelfinavir clearance may occur. Diabetes: New onset diabetes and exacerbation of pre-existing diabetes mellitus has been reported in postmarking surveillance. Hemophilia: There have been reports of increased bleeding, including skin hematomas and hemarthrosis in patients with hemophilia type A and B treated with protease inhibitors. A causal relationship has not been established. Phenylketonuria: Nelfinavir powder contains 11.2 mg phenylalanine per gm of powder.
PATIENT CARE CONSIDERATIONS |
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Copyright © 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts